Karen has a evil, yet caring personality. She always wants the best in her allies, especially Galaximus, and will help her friends in anyway she can. She is also very smart, being a computer. She excels at science, calculations, and scheming, in particular.
Karen is good friends with Galaximus, often helping her devise plans to defeat the Gang. She does think Galaximus is a tad dumb at times, though she never tells her that.
She is an enemy to Karen due to her alliance with the Gang and her history with Galaximus. While she does not hate Jenny on her own terms, Karen nonetheless considers her a threat.
Karen and Patrick know each other due to them both living in Bikini Bottom. Karen sees Patrick as nothing more than an idiot, and thus, never worries about him posing a danger.
In secret, these two get along very well and share a deep friendship, due to them both loving science, and because Karen is a computer while Nebula has a robot suit.
The rest of the Gang
Due to them being a danger to the Galactic Army, Karen sees the Gang as a threat, more so than anyone else. She seems to know at least a little about all their members, and uses that info to help the others beat them.